BDBM653327 (P)-1-(6-((7R)-7-(1,4- dimethyl-1H-pyrazol-5- yl)-3-methyl-4-(6- methyl-1H-indazol-7- yl)-5,6,7,8-tetrahydro-2- quinolinyl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 14-98

SMILES Cc1cnn(C)c1[C@@H]1CCc2c(C1)nc(N1CCC3(CN(C3)C(=O)C=C)C1)c(C)c2-c1c(C)ccc2cnn(C)c12

InChI Key InChIKey=XXVZWXSDPGQEJJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653327   

LigandPNGBDBM653327(US20240059703, Example 14-98 | (P)-1-(6-((7R)-7-(1...)
Affinity DataIC50: 71nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
US Patent