BDBM653265 1-(6-(3,7,7-trimethyl-4- (6-methyl-1- (2H3)methyl-1H-indazol- 7-yl)-7,8-dihydro-5H- pyrano[4,3-b]pyridin-2- yl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 14-100::US20240059703, Example 14-36::US20240059703, Example 14-37::US20240059703, Example 14-99

SMILES Cc1ccc2cnn(C)c2c1-c1c(C)c(nc2CC(C)(C)OCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=IYMFZKRLFDSOOJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 653265   

LigandPNGBDBM653265(US20240059703, Example 14-36 | 1-(6-(3,7,7-trimeth...)
Affinity DataIC50: 71nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653265(US20240059703, Example 14-36 | 1-(6-(3,7,7-trimeth...)
Affinity DataIC50: 226nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653265(US20240059703, Example 14-36 | 1-(6-(3,7,7-trimeth...)
Affinity DataIC50: 478nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653265(US20240059703, Example 14-36 | 1-(6-(3,7,7-trimeth...)
Affinity DataIC50: 602nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent