BDBM653300 1-(6-(4-(1,6-dimethyl- 1H-indazol-7-yl)-3- fluoro-7,7-dimethyl-7,8- dihydro-5H-pyrano[4,3- b]pyridin-2-yl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 14-101::US20240059703, Example 14-102::US20240059703, Example 14-71

SMILES Cc1ccc2cnn(C)c2c1-c1c(F)c(nc2CC(C)(C)OCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=JSDPWZMGRIONKX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653300   

LigandPNGBDBM653300(US20240059703, Example 14-71 | 1-(6-(4-(1,6-dimeth...)
Affinity DataIC50: 301nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653300(US20240059703, Example 14-71 | 1-(6-(4-(1,6-dimeth...)
Affinity DataIC50: 781nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653300(US20240059703, Example 14-71 | 1-(6-(4-(1,6-dimeth...)
Affinity DataIC50: 5.56E+4nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent