BDBM653255 1-(6-(4-(3-hydroxy-1- naphthalenyl)-3,7,7- trimethyl-7,8-dihydro- 5H-pyrano[4,3- b]pyridin-2-yl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 14-103::US20240059703, Example 14-26::US20240059703, Example 14-35

SMILES Cc1c(nc2CC(C)(C)OCc2c1-c1cc(O)cc2ccccc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=VWZSDRZHJLCNPV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653255   

LigandPNGBDBM653255(1-(6-(4-(3-hydroxy-1- naphthalenyl)-3,7,7- trimeth...)
Affinity DataIC50: 45nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653255(1-(6-(4-(3-hydroxy-1- naphthalenyl)-3,7,7- trimeth...)
Affinity DataIC50: 67nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653255(1-(6-(4-(3-hydroxy-1- naphthalenyl)-3,7,7- trimeth...)
Affinity DataIC50: 5.62E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent