BDBM653333 1-(6-(7-methyl-8-(5- methyl-1H-indazol-4- yl)-3,4-dihydro-1H-2- benzopyran-6-yl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 14-104

SMILES Cc1ccc2[nH]ncc2c1-c1c(C)c(cc2CCOCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=HRBJKPKGPDZTLG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653333   

LigandPNGBDBM653333(US20240059703, Example 14-104 | 1-(6-(7-methyl-8-(...)
Affinity DataIC50: 242nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent