BDBM653334 1-(6-(4-(6-chloro-1,5- dimethyl-1H-indazol-7- yl)-3,7,7-trimethyl-7,8- dihydro-5H-pyrano[4,3- b]pyridin-2-yl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 14-105

SMILES Cc1cc2cnn(C)c2c(c1Cl)-c1c(C)c(cc2CCOCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=JRZBULQZBCSABE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653334   

LigandPNGBDBM653334(US20240059703, Example 14-105 | 1-(6-(4-(6-chloro-...)
Affinity DataIC50: 54nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
US Patent