BDBM655271 2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-4-methyl-1H-pyrrolo[2,3-c]pyridin-5-yl)piperazin-1-yl)-N,N-dimethylacetamide::US11912703, Example 352

SMILES CC(C)c1c([nH]c2cnc(N3CCN(CC(=O)N(C)C)CC3)c(C)c12)-c1cn2ncnc2c(C)c1C

InChI Key InChIKey=OHYRFJQBBDEFLE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 655271   

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655271(US11912703, Example 352 | 2-(4-(2-(7,8-dimethyl-[1...)
Affinity DataIC50: 0.730nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655271(US11912703, Example 352 | 2-(4-(2-(7,8-dimethyl-[1...)
Affinity DataIC50: 14nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655271(US11912703, Example 352 | 2-(4-(2-(7,8-dimethyl-[1...)
Affinity DataIC50: 1.98E+4nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent