BDBM655156 US11912703, Example 144::US11912703, Example 210::US11912703, Example 60::US11912703, Example 95

SMILES COc1cc(cn2ncnc12)-c1[nH]c2cnc(cc2c1C(C)C)C1CCC(C1)NCC(C)(C)C

InChI Key InChIKey=FHCYAHVNXQEUSG-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 655156   

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 1.20nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 5nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 6.60nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 14nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 14nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 34nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 35nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 41nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 502nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 1.08E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 1.25E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655156(US11912703, Example 95 | US11912703, Example 144 |...)
Affinity DataIC50: 1.38E+3nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent