BDBM6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955

SMILES: CN1c2c(cnc(n2)Nc3cccc(c3)SC)C=C(C1=O)c4c(cccc4Cl)Cl

InChI Key: InChIKey=VAARYSWULJUGST-UHFFFAOYSA-N

Data: 3 KI  25 IC50  451 Kd  1 EC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 479 hits for monomerid = 6568   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24.5	n/a	n/a	n/a	n/a	7.5	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	28	n/a	<3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 [596-900] (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ephrin type-A receptor 2 [596-900] (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek1 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek2 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek5 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek11 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 4 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein kinase C eta type (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit alpha (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D2 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase TNNI3K (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit beta (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 11A (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-2 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-6 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
SRSF protein kinase 2 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit alpha (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Human)	BDBM6568 (PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair