BDBM66082 (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]amino]glutaric acid;hydrate::(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;hydrate::(2S)-2-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid;hydrate::(2S)-2-[[[4-[(2,4-diamino-6-pteridinyl)methyl-methylamino]phenyl]-oxomethyl]amino]pentanedioic acid;hydrate::L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [CAS]::MLS001401431::SMR000449324::US11530198, Example Methotrexate::cid_165528

SMILES: CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI Key: InChIKey=FBOZXECLQNJBKD-UHFFFAOYSA-N

Data: 8 KI  80 IC50  3 Kd  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 94 hits for monomerid = 66082   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.58E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.07E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Staphylococcus aureus)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 4 (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Staphylococcus aureus)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 4 (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Methionine synthase (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vacuolar aminopeptidase 1 (Baker's yeast)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	5.18E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.45E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.14E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.29E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.34E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.51E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.16E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.32E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Bovine)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.891	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Plasmodium Falciparum)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Bifunctional purine biosynthesis protein ATIC/Thymidylate synthase/Trifunctional purine biosynthetic protein adenosine-3 (Human)	BDBM66082 (SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair