BDBM6646 3-(7-hydroxynaphthalen-1-yl)-1-phenylurea::Diarylurea deriv. 1a::N-(7-Hydroxy-1-naphthyl)-N -phenylurea

SMILES Oc1ccc2cccc(NC(=O)Nc3ccccc3)c2c1

InChI Key InChIKey=UUAPFBCLZLDKHG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 6646   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM6646(3-(7-hydroxynaphthalen-1-yl)-1-phenylurea | Diaryl...)
Affinity DataIC50:  1.20E+5nMT: 2°CAssay Description:In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 45 min in buffer that contained 50 uM ATP, and d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Bayer Yakuhin

Curated by ChEMBL
LigandPNGBDBM6646(3-(7-hydroxynaphthalen-1-yl)-1-phenylurea | Diaryl...)
Affinity DataIC50:  53nMAssay Description:Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Bayer Yakuhin

Curated by ChEMBL
LigandPNGBDBM6646(3-(7-hydroxynaphthalen-1-yl)-1-phenylurea | Diaryl...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed