BDBM6760 (+)-K-252a::CHEMBL281948::K-252a::methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-16-carboxylate

SMILES: COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13

InChI Key: InChIKey=KOZFSFOOLUUIGY-UHFFFAOYSA-N

Data: 1 KI  25 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 6760   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C theta type (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
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O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
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O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
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Rho-associated protein kinase 2 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>500	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 11 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 11 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase D1 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<25	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
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Myosin light chain kinase, smooth muscle (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	7.0	22
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cAMP-dependent protein kinase (Rabbit)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
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Myosin light chain kinase, smooth muscle (Chicken)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C zeta type (Rat)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
O94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein kinase C zeta type (Rat)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	427	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 10 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase 9 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	22	n/a	n/a	n/a	n/a	7.2	37
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Serine/threonine-protein kinase pim-1 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	150	n/a	n/a	n/a	n/a	7.6	30
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Human)	BDBM6760 (CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...) Show SMILES Show InChI	GoogleScholar	UniChem		20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair