BDBM6878 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n::5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbothioamide

SMILES: c1cc(c(c(c1)F)NC(=S)n2c(nc(n2)Nc3ccc(cc3)S(=O)(=O)N)N)F

InChI Key: InChIKey=ARIOBGGRZJITQX-UHFFFAOYSA-N

Data: 24 IC50

PDB links: 10 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 6878   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 5 activator 1 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity protein kinase CLK3 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity protein kinase CLK1 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
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Interferon-induced, double-stranded RNA-activated protein kinase (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	8.0	30
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Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Calcium/calmodulin-dependent protein kinase type II subunit alpha (Rat)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 1 (Rat)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Casein kinase I isoform delta (Rat)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin receptor (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta [7-25] (Rabbit)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Rat)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM6878 (5-amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphen...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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