BDBM7458 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one::Apigenin::Apigenin (2)::Apigenin (3)::Apigenin (7)::Apigenin, 13::CHEMBL28::Naringenin, 18::US10278929, Apigenin::US11337935, Compound Apigenin::acs.jmedchem.1c00409_ST.789::cid_5280443::jm5b01461, Compound 90

SMILES: c1cc(ccc1C2=CC(=O)c3c(cc(cc3O2)O)O)O

InChI Key: InChIKey=KZNIFHPLKGYRTM-UHFFFAOYSA-N

Data: 25 KI  131 IC50  4 Kd  7 EC50  1 ITC

PDB links: 11 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 170 hits for monomerid = 7458   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin homolog/dependent kinase 6 (Human-SaHV-2)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	7.0	30
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Cyclin-dependent kinase 5 activator 1 [99-307] (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	7.0	30
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Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Spiny starfish)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	7.0	30
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Glycogen synthase kinase-3 beta (Rat)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	30
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Transthyretin (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	653	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase pim-1 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	940	n/a	n/a	n/a	n/a	7.0	30
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Glycogen synthase kinase-3 beta (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.95E+4	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	37
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Mitogen-activated protein kinase 10 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	37
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17-beta-hydroxysteroid dehydrogenase type 3 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.13E+4	n/a	n/a	n/a	n/a	7.45	37
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17-beta-hydroxysteroid dehydrogenase type 3 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.64E+4	n/a	n/a	n/a	n/a	7.45	37
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Transthyretin (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	653	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase B (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.96E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 3 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.40E+4	n/a	n/a	n/a	n/a	7.4	37
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Tyrosine-protein phosphatase non-receptor type 1 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	6.0	n/a
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Acetylcholinesterase (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.43E+4	n/a	n/a	n/a	n/a	8.0	25
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Replicase polyprotein 1ab (SARS-CoV)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (SARS-CoV)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.81E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Transthyretin (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	653	n/a	n/a	n/a	n/a	n/a	n/a
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Homeobox protein Nkx-2.5/Transcription factor GATA-4 (Mouse)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 1B1 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
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Amine oxidase [flavin-containing] A (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
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Amine oxidase [flavin-containing] B (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Xanthine dehydrogenase/oxidase (Bovine)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Myocilin (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.16E+4	n/a	n/a	n/a	n/a	n/a
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Amine oxidase [flavin-containing] A (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Neutrophil elastase (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
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17-beta-hydroxysteroid dehydrogenase type 2 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Amine oxidase [flavin-containing] A (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Dipeptidyl peptidase 4 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Pyruvate kinase PKM (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
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Estrogen receptor beta (Sheep)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a
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Neuraminidase (Influenza A virus)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Neuraminidase (Influenza A virus)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.89E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Neuraminidase (Influenza A virus)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Reverse transcriptase (Human immunodeficiency virus type 1)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.43E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 1 (Sheep)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Prostaglandin G/H synthase 2 (Sheep)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Neuraminidase (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Neuraminidase (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (SARS-CoV)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.81E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 6 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
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D-alanine--D-alanine ligase (Helicobacter pylori (strain HPAG1))	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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D-alanine--D-alanine ligase B (Escherichia coli (strain K12))	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.63E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Neuraminidase (Influenza A virus)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.89E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Beta-secretase 1 (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.85E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Acetylcholinesterase (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM7458 (Naringenin, 18 | 5,7-dihydroxy-2-(4-hydroxyphenyl)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+5	n/a	n/a	n/a	n/a	n/a	n/a
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