BDBM7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355

SMILES: CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1

InChI Key: InChIKey=BTIHMVBBUGXLCJ-UHFFFAOYSA-N

Data: 5 KI  193 IC50  339 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 568 hits for monomerid = 7533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Spiny starfish)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Spiny starfish)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	450	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	450	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Bovine)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
cGMP-dependent protein kinase 1 (Bovine)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Rat)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+5	n/a	n/a	n/a	n/a	n/a	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Rat)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Spiny starfish)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	350	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	400	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Rat)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	370	n/a	n/a	n/a	n/a	7.2	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	330	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	270	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	800	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	230	n/a	n/a	n/a	n/a	7.5	30
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	7.4	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	7.4	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 [R432A] (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	7.4	23
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform delta (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform gamma-3 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Mouse)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK3 (Mouse)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK4 (Mouse)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Pig)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 (Mouse)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Human)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase (Pig)	BDBM7533 (2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair