BDBM758239 (S)-2-(3-(3,3-difluoro-1-(fluoro(4- methyl-4H-1,2,4-triazol-3- yl)methyl)cyclobutyl)phenyl)-6- ((isopropyl(methyl)amino)methyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 420

SMILES CC(C)N(C)Cc1cc2c(c(C(F)(F)F)c1)CN(c1cccc(C3([C@H](F)c4nncn4C)CC(F)(F)C3)c1)C2=O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 758239   

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM758239((S)-2-(3-(3,3-difluoro-1-(fluoro(4- methyl-4H-1,2,...)
Affinity DataIC50: 220nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM758239((S)-2-(3-(3,3-difluoro-1-(fluoro(4- methyl-4H-1,2,...)
Affinity DataIC50: 240nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent