BDBM75840 (5Z)-5-[4-(dimethylamino)benzylidene]-2-piperidino-2-thiazolin-4-one::(5Z)-5-[[4-(dimethylamino)phenyl]methylidene]-2-(1-piperidinyl)-4-thiazolone::(5Z)-5-[[4-(dimethylamino)phenyl]methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one::5-(4-Dimethylamino-benzylidene)-2-piperidin-1-yl-thiazol-4-one::MLS001202563::SMR000513498::cid_715217

SMILES CN(C)c1ccc(\C=C2/SC(=NC2=O)N2CCCCC2)cc1

InChI Key InChIKey=LWVUAWHWEMYMOW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 75840   

TargetInsulin-degrading enzyme(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM75840(SMR000513498 | (5Z)-5-[[4-(dimethylamino)phenyl]me...)
Affinity DataIC50: 1.79E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM75840(SMR000513498 | (5Z)-5-[[4-(dimethylamino)phenyl]me...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM75840(SMR000513498 | (5Z)-5-[[4-(dimethylamino)phenyl]me...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM75840(SMR000513498 | (5Z)-5-[[4-(dimethylamino)phenyl]me...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM75840(SMR000513498 | (5Z)-5-[[4-(dimethylamino)phenyl]me...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2013
Entry Details Article
PubMed