BDBM77145 9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine::PMPA prodrug::Tenofovir::Tenofovir disoproxil::US12049474, Compound TDF

SMILES: CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C

InChI Key: InChIKey=JFVZFKDSXNQEJW-UHFFFAOYSA-N

Data: 11 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 77145   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gag-Pol polyprotein [588-1147,M628L,N654N,K657R,T802F,K807E] (HIV-1)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Gag-Pol polyprotein [588-1147,M628L,D654N,M771V,L797W,T802Y] (HIV-1)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gag-Pol polyprotein [588-1147,M628L,D654N,M771V,L797W,T802Y] (HIV-1)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>8.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gag-Pol polyprotein [588-1147,V662I,F664L,F703Y,Q738M,M771V] (HIV-1)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>6.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Gag-Pol polyprotein [588-1147,M628L,T656S,M771V,L797W,T802Y] (HIV-1)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>6.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Gag-Pol polyprotein [588-1147,K652R,M771V] (HIV-1)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 3 (Human)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 2 (Human)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 4 (Human)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM77145 (9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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