BindingDB PrimarySearch

BDBM77970 3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-propan-1-amine;hydrochloride::3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethyl-1-propanamine;hydrochloride::3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride::3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-dimethyl-amine;hydrochloride::CHLORIMIPRAMINE::CLOMIPRAMINE::CLOMIPRAMINE HYDROCHLORIDE::CLOMIPRIMINE::MLS000028511::SMR000058295::cid_68539::med.21724, Compound Clomipramine

SMILES: CN(C)CCCN1c2ccccc2CCc3c1cc(cc3)Cl

InChI Key: InChIKey=GDLIGKIOYRNHDA-UHFFFAOYSA-N

Data: 59 KI 30 IC50 1 Kd 3 EC50

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 93 hits for monomerid = 77970
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
ATP-binding cassette sub-family C member 3 (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent N-type calcium channel subunit alpha-1B (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Sodium-dependent noradrenaline transporter (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Trypanothione reductase (Trypanosoma cruzi)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Envelope glycoprotein (ZEBOV)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.18E+5	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 4 (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Trypanothione reductase (Trypanosoma cruzi)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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ATP-binding cassette sub-family C member 2 (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Bile salt export pump (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.74E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase ROS (Mouse)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (SARS-CoV)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a
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Orf1a protein (MERS-CoV)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	9.33E+3	n/a	n/a	n/a	n/a
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Mitochondrial import inner membrane translocase subunit TIM10 (Baker's yeast)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Sodium-dependent serotonin transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Sodium-dependent dopamine transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H1 receptor (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Alpha-1A adrenergic receptor (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
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Histamine H2 receptor (Guinea pig)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	720	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 1 (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.93E+4	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
Trypanothione reductase (Trypanosoma cruzi)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Mouse)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Mouse)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Trypanothione reductase (Trypanosoma brucei brucei)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 1/2/3 subunit alpha (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Bile salt export pump (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Proteasome subunit alpha type-6 (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	1.24E+4	n/a	n/a	7.5	37
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Sodium-dependent serotonin transporter (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium-dependent serotonin transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	0.470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium-dependent serotonin transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1A adrenergic receptor (Human)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Serotonin 2 (5-HT2) receptor (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	8.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	9.42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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5-hydroxytryptamine receptor 2A (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Norepinephrine transporter (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	14.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Alpha-1A adrenergic receptor (Rat)	BDBM77970 (CLOMIPRAMINE HYDROCHLORIDE \| CHLORIMIPRAMINE \| 3-(...) Show SMILES Show InChI	GoogleScholar	UniChem	15.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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TBA				More data for this Ligand-Target Pair

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