BindingDB PrimarySearch

BDBM16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US11912663, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239

SMILES: CNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl

InChI Key: InChIKey=MLDQJTXFUGDVEO-UHFFFAOYSA-N

Data: 26 KI 366 IC50 1273 Kd 3 EC50

PDB links: 8 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1705 hits for monomerid = 16673
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	95.2	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	95.2	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	32.4	n/a	n/a	n/a	n/a	n/a	n/a
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RAF proto-oncogene serine/threonine-protein kinase [305-648] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	8.2	32
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Serine/threonine-protein kinase B-raf [409-765] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	22	n/a	n/a	n/a	n/a	8.2	32
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Serine/threonine-protein kinase B-raf [410-766,V600E] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	38	n/a	n/a	n/a	n/a	8.2	32
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Vascular endothelial growth factor receptor 2 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	90	n/a	n/a	n/a	n/a	7.5	22
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Vascular endothelial growth factor receptor 2 (Mouse)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	22
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Vascular endothelial growth factor receptor 3 (Mouse)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	20	n/a	n/a	n/a	n/a	7.5	22
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Platelet-derived growth factor receptor beta (Mouse)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	57	n/a	n/a	n/a	n/a	7.5	22
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Aromatase (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	58	n/a	n/a	n/a	n/a	7.5	22
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Mast/stem cell growth factor receptor Kit (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	68	n/a	n/a	n/a	n/a	7.5	22
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Fibroblast growth factor receptor 1 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	580	n/a	n/a	n/a	n/a	7.5	22
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Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [V804L] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	95.2	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [V804M] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	32.4	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	89.6	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
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RAF proto-oncogene serine/threonine-protein kinase (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1	n/a	n/a	n/a	n/a	7.8	22
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Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase B-raf [V600E] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	43	n/a	n/a	n/a	n/a	7.2	22
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Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	160	n/a	n/a	n/a	7.4	25
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Aurora kinase B (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a
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Aurora kinase C (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	210	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase receptor UFO (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 19 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	250	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 7 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	140	n/a	n/a	n/a	7.4	23
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Cyclin-dependent kinase 8 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	310	n/a	n/a	n/a	7.4	23
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Macrophage colony-stimulating factor 1 receptor (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	28	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.5	n/a	n/a	n/a	7.4	25
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Discoidin domain-containing receptor 2 [A642S] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	6.60	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 3 [1-975] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	370	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.30E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-B receptor 4 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase 15 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	46	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	31	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	13	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	30	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	82	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	79	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	11	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 3 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	95	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	510	n/a	n/a	n/a	7.4	25
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Mer (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
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MAP kinase-interacting serine/threonine-protein kinase 1 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a
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MAP kinase-interacting serine/threonine-protein kinase 2 (Human)	BDBM16673 (Xarelto \| BAY439006 \| CHEMBL1336 \| BAY 43-9006 \| 4...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a
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