BDBM8125 (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-methylpropyl)sulfonamido]-3-hydroxy-1-phenylbutan-2-yl]carbamate::CHEMBL1323::Darunavir::Darunavir (DRV)::TMC-114::UIC-94017::US10806794, Compound Darunavir

SMILES: CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CO[C@H]2OCC[C@@H]12)S(=O)(=O)c1ccc(N)cc1

InChI Key: InChIKey=CJBJHOAVZSMMDJ-UHFFFAOYSA-N

Data: 60 KI  30 IC50  1 Kd  9 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 101 hits for monomerid = 8125   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gag-Pol polyprotein [489-892] (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.25	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
HIV WT-A pol protein (wild-type clade A) (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-892,N526H,R530K,V566I,I582L,V648I,Q690K,I723V,C750S,T788A,Q795E,T874A,V881I,P882Q] (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.150	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
HIV WT-C pol protein (wild-type clade C) (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.180	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
MDRC4 (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
MDR1 (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.230	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
HIV-1 protease (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0130	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	112	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.870	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0610	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.58E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily D member 3 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.31E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily E/KQT member 1 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily E/KQT member 1 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.16E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.58E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		0.000147	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		0.000200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
HIV-1 protease (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.00100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
HIV-1 protease (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		0.00100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
HIV-1 protease (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		0.00400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
HIV-1 protease (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		0.00430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [484-582,Q491K,I494L,I497V,V499I,E519D,R541K,D544E,Q553K,L573M] (Human immunodeficiency virus)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		0.00500	-15.4	n/a	n/a	n/a	n/a	n/a	4.7	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		0.00500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.00500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		0.00530	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protease (Human immunodeficiency virus type 1)	BDBM8125 (Darunavir (DRV) | CHEMBL1323 | (3R,3aS,6aR)-hexahy...) Show SMILES Show InChI	GoogleScholar	UniChem		0.00800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair