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BDBM8175 N-[4-chloro-3-(trifluoromethyl)phenyl]-4-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyridazin-3-yl]pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 66

SMILES: Fc1ccc(cc1)-c1nn2ncccc2c1-c1ccnc(Nc2ccc(Cl)c(c2)C(F)(F)F)n1

InChI Key: InChIKey=OFLZPIHQIBEOQU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 8175   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8175
PNG
(N-[4-chloro-3-(trifluoromethyl)phenyl]-4-[2-(4-flu...)
Show SMILES Fc1ccc(cc1)-c1nn2ncccc2c1-c1ccnc(Nc2ccc(Cl)c(c2)C(F)(F)F)n1
Show InChI InChI=1S/C23H13ClF4N6/c24-17-8-7-15(12-16(17)23(26,27)28)31-22-29-11-9-18(32-22)20-19-2-1-10-30-34(19)33-21(20)13-3-5-14(25)6-4-13/h1-12H,(H,29,31,32)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


J Med Chem 47: 4716-30 (2004)


Article DOI: 10.1021/jm040063i
BindingDB Entry DOI: 10.7270/Q2VM49HJ
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 2 (CDK2)


(Homo sapiens (Human))
BDBM8175
PNG
(N-[4-chloro-3-(trifluoromethyl)phenyl]-4-[2-(4-flu...)
Show SMILES Fc1ccc(cc1)-c1nn2ncccc2c1-c1ccnc(Nc2ccc(Cl)c(c2)C(F)(F)F)n1
Show InChI InChI=1S/C23H13ClF4N6/c24-17-8-7-15(12-16(17)23(26,27)28)31-22-29-11-9-18(32-22)20-19-2-1-10-30-34(19)33-21(20)13-3-5-14(25)6-4-13/h1-12H,(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...


J Med Chem 47: 4716-30 (2004)


Article DOI: 10.1021/jm040063i
BindingDB Entry DOI: 10.7270/Q2VM49HJ
More data for this
Ligand-Target Pair