BDBM8217 N-(2-methylphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 18

SMILES Cc1ccccc1Nc1nccc(n1)-c1cnn2ncccc12

InChI Key InChIKey=JJWMXOUQWRDJLK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8217   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8217(N-(2-methylphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-y...)
Affinity DataIC50:  6.00E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
University Of Sussex

Curated by ChEMBL
LigandPNGBDBM8217(N-(2-methylphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-y...)
Affinity DataIC50:  64nMAssay Description:Inhibition of recombinant human N-terminal Hex-tagged DYRK1A (127 to 485 residues) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8217(N-(2-methylphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-y...)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of human GSK3beta using biotinylated-aminohexyl-Ala-Ala-Ala-Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser(PO3)-Tyr-Arg-amide as substrate af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed