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BDBM82509 Melatonin,6-Hydroxy::melatonin, 6-Hydroxy

SMILES: COc1cc2c(CCNC(C)=O)c[nH]c2cc1O

InChI Key: InChIKey=OMYMRCXOJJZYKE-UHFFFAOYSA-N

Data: 11 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 82509   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melatonin receptor


(Homo sapiens (Human))
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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PubMed
0.540n/an/an/an/an/an/an/an/a



Glaxo Wellcome Research and Development, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 285: 1239-45 (1998)


BindingDB Entry DOI: 10.7270/Q2PK0DPM
More data for this
Ligand-Target Pair
Melatonin receptor


(Homo sapiens (Human))
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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PubMed
1.69n/an/an/an/an/an/an/an/a



Glaxo Wellcome Research and Development, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 285: 1239-45 (1998)


BindingDB Entry DOI: 10.7270/Q2PK0DPM
More data for this
Ligand-Target Pair
Melatonin receptor


(Homo sapiens (Human))
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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Article
PubMed
2n/an/an/an/an/an/an/an/a



Massachusetts General Hospital

Curated by PDSP Ki Database




Neuron 13: 1177-85 (1994)


Article DOI: 10.1016/0896-6273(94)90055-8
BindingDB Entry DOI: 10.7270/Q27P8WXK
More data for this
Ligand-Target Pair
Melatonin receptor


(Homo sapiens (Human))
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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PubMed
2.23n/an/an/an/an/an/an/an/a



Glaxo Wellcome Research and Development, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 285: 1239-45 (1998)


BindingDB Entry DOI: 10.7270/Q2PK0DPM
More data for this
Ligand-Target Pair
Melatonin


(Sheep)
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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PubMed
3n/an/an/an/an/an/an/an/a



Massachusetts General Hospital

Curated by PDSP Ki Database




Neuron 13: 1177-85 (1994)


Article DOI: 10.1016/0896-6273(94)90055-8
BindingDB Entry DOI: 10.7270/Q27P8WXK
More data for this
Ligand-Target Pair
Melatonin receptor


(Homo sapiens (Human))
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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Article
PubMed
5.5n/an/an/an/an/an/an/an/a



Northwestern University

Curated by PDSP Ki Database




Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997)


Article DOI: 10.1007/pl00004956
BindingDB Entry DOI: 10.7270/Q2416VKF
More data for this
Ligand-Target Pair
Melatonin


(RABBIT)
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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Article
PubMed
6.90n/an/an/an/an/an/an/an/a



Northwestern University

Curated by PDSP Ki Database




Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997)


Article DOI: 10.1007/pl00004956
BindingDB Entry DOI: 10.7270/Q2416VKF
More data for this
Ligand-Target Pair
Melatonin


(GUINEA PIG)
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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PubMed
10.2n/an/an/an/an/an/an/an/a



Glaxo Wellcome Research and Development, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 285: 1239-45 (1998)


BindingDB Entry DOI: 10.7270/Q2PK0DPM
More data for this
Ligand-Target Pair
Melatonin


(GUINEA PIG)
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
UniProtKB/SwissProt

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CHEBI
KEGG
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UniChem

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PubMed
25.1n/an/an/an/an/an/an/an/a



Glaxo Wellcome Research and Development, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 285: 1239-45 (1998)


BindingDB Entry DOI: 10.7270/Q2PK0DPM
More data for this
Ligand-Target Pair
Melatonin receptor


(Homo sapiens (Human))
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
PDB

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Article
PubMed
40.2n/an/an/an/an/an/an/an/a



Northwestern University

Curated by PDSP Ki Database




Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997)


Article DOI: 10.1007/pl00004956
BindingDB Entry DOI: 10.7270/Q2416VKF
More data for this
Ligand-Target Pair
Melatonin


(RABBIT)
BDBM82509
PNG
(Melatonin,6-Hydroxy | melatonin, 6-Hydroxy)
Show SMILES COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
Show InChI InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
UniProtKB/TrEMBL

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CHEBI
KEGG
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Article
PubMed
74n/an/an/an/an/an/an/an/a



Rowett Research Institute

Curated by PDSP Ki Database




Neurochem Int 24: 101-46 (1994)


Article DOI: 10.1016/j.bioorg.2015.03.004
BindingDB Entry DOI: 10.7270/Q2SJ1J42
More data for this
Ligand-Target Pair