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BDBM8266 2-chloro-5-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-3-yl)amino]benzoic acid::4-arylmaleimide deriv. 6-w

SMILES: OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccccc2)ccc1Cl

InChI Key: InChIKey=RLMJMTPRBLGCRP-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 8266   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM8266
PNG
(2-chloro-5-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyr...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccccc2)ccc1Cl
Show InChI InChI=1S/C17H11ClN2O4/c18-12-7-6-10(8-11(12)17(23)24)19-14-13(15(21)20-16(14)22)9-4-2-1-3-5-9/h1-8H,(H,23,24)(H2,19,20,21,22)
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 143n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of recombinant GSK3-beta


J Med Chem 51: 2062-77 (2008)


Article DOI: 10.1021/jm7009765
BindingDB Entry DOI: 10.7270/Q20Z744C
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM8266
PNG
(2-chloro-5-[(2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyr...)
Show SMILES OC(=O)c1cc(NC2=C(C(=O)NC2=O)c2ccccc2)ccc1Cl
Show InChI InChI=1S/C17H11ClN2O4/c18-12-7-6-10(8-11(12)17(23)24)19-14-13(15(21)20-16(14)22)9-4-2-1-3-5-9/h1-8H,(H,23,24)(H2,19,20,21,22)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 143n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair