BDBM85507 CAS_4394-00-7::NSC_4488::Niflumic acid::Niflumic acid (Hit 16)::US10278929, Niflumic acid::US11337935, Compound Niflumic-acid::US20240002326, Compound Niflumic acid

SMILES: c1cc(cc(c1)Nc2c(cccn2)C(=O)O)C(F)(F)F

InChI Key: InChIKey=JZFPYUNJRRFVQU-UHFFFAOYSA-N

Data: 4 KI  15 IC50  6 Kd  5 EC50  1 ITC

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 85507   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-type lectin domain family 4 member M (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transthyretin (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transthyretin (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A1 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
UDP-glucuronosyltransferase 1A1 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.08E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.11E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	4.02E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transcriptional enhancer factor TEF-3 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
C-type lectin domain family 4 member K (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transthyretin (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	289	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transcriptional enhancer factor TEF-3 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transcriptional enhancer factor TEF-3 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transcriptional enhancer factor TEF-3 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transcriptional enhancer factor TEF-3 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transcriptional enhancer factor TEF-3 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.75E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transthyretin (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	289	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transcription factor SOX-18 (Mouse)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.75E+5	n/a	n/a	n/a	n/a	7.5	37
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transthyretin (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	289	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [33-574] (Rat)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.62E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transthyretin (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	592	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
G-protein coupled receptor 35 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		3.61E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...) Show SMILES Show InChI	GoogleScholar	UniChem		>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 85507

Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kcal/mole	-TΔS° kcal/mole	ΔH° kcal/mole	log K	pH	Temp °C
Transthyretin (Human)	BDBM85507 (NSC_4488 | CAS_4394-00-7 | Niflumic acid (Hit 16) ...)	GoogleScholar			-8.48	9.54	-18.1	6.22	7.5	25
TBA					Details of this binding reaction