BDBM85515 Ampyrone::CAS_83-07-8::EN300-17058::NSC_2151::US11643395, Compound 9

SMILES Cc1c(N)c(=O)n(-c2ccccc2)n1C

InChI Key InChIKey=RLFWWDJHLFCNIJ-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 85515   

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM85515(Ampyrone | CAS_83-07-8 | EN300-17058 | NSC_2151 | ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM85515(Ampyrone | CAS_83-07-8 | EN300-17058 | NSC_2151 | ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM85515(Ampyrone | CAS_83-07-8 | EN300-17058 | NSC_2151 | ...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Mus musculus)
Philipps-Universit£T

Curated by ChEMBL
LigandPNGBDBM85515(Ampyrone | CAS_83-07-8 | EN300-17058 | NSC_2151 | ...)
Affinity DataIC50:  1.00E+6nMAssay Description:Inhibition of COX-1 in C57BL/6 mouse brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Individual

US Patent
LigandPNGBDBM85515(Ampyrone | CAS_83-07-8 | EN300-17058 | NSC_2151 | ...)
Affinity DataIC50:  6.97E+4nMAssay Description:In-vitro butyryl cholinesterase inhibitory activity was performed in 96-well microplates, 0.5 mM test compound in methanol, was incubated with 20 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Philipps-Universit£T

Curated by ChEMBL
LigandPNGBDBM85515(Ampyrone | CAS_83-07-8 | EN300-17058 | NSC_2151 | ...)
Affinity DataIC50:  1.00E+6nMAssay Description:Inhibition of COX-2 in C57BL/6 mouse brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM85515(Ampyrone | CAS_83-07-8 | EN300-17058 | NSC_2151 | ...)
Affinity DataIC50:  3.41E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Minia University

Curated by ChEMBL
LigandPNGBDBM85515(Ampyrone | CAS_83-07-8 | EN300-17058 | NSC_2151 | ...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver estera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM85515(Ampyrone | CAS_83-07-8 | EN300-17058 | NSC_2151 | ...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver est...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed