BDBM85747 CAS_442-52-4::CLEMIZOLE HYDROCHLORIDE::NSC_2782::clemizole
SMILES Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
InChI Key InChIKey=CJXAEXPPLWQRFR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 85747
TargetHistamine H4 receptor(Homo sapiens (Human))
The Centre For Addiction And Mental Health
Curated by PDSP Ki Database
The Centre For Addiction And Mental Health
Curated by PDSP Ki Database
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HO-1 in Sprague-Dawley rat spleen microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas ch...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of HO-2 in Sprague-Dawley rat brain microsomal fractions assessed as carbon monoxide formation from methemalbumin after 10 mins by gas chr...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
University Of Nebraska Medical Center
Curated by ChEMBL
University Of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of YFP-tagged human TRPC6 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 4(Mus musculus)
University Of Nebraska Medical Center
Curated by ChEMBL
University Of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of YFP-tagged mouse TRPC4 beta expressed in thapsigargin treated HEK293 cells co-expressing M3 receptor assessed as reduction in carbachol...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
University Of Nebraska Medical Center
Curated by ChEMBL
University Of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CFP-tagged rat TRPV1 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
TargetShort transient receptor potential channel 7(Mus musculus)
University Of Nebraska Medical Center
Curated by ChEMBL
University Of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 2.65E+4nMAssay Description:Inhibition of YFP-tagged mouse TRPC7 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...More data for this Ligand-Target Pair
TargetHeat sensitive channel TRPV3(Rattus norvegicus)
University Of Nebraska Medical Center
Curated by ChEMBL
University Of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of YFP-tagged rat TRPV3 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 4(Mus musculus)
University Of Nebraska Medical Center
Curated by ChEMBL
University Of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of YFP-tagged mouse TRPV4 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 2(Rattus norvegicus)
University Of Nebraska Medical Center
Curated by ChEMBL
University Of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of YFP-tagged rat TRPV2 expressed in HEK293 cells assessed as reduction in calcium level by fluo-4 dye based fluorescence assayMore data for this Ligand-Target Pair
TargetShort transient receptor potential channel 5(Mus musculus)
University Of Nebraska Medical Center
Curated by ChEMBL
University Of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of mouse TRPC5 expressed in thapsigargin treated HEK293/TREx cells assessed as reduction in intracellular calcium level in presence of GPC...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junion University
US Patent
The Board Of Trustees Of The Leland Stanford Junion University
US Patent
Affinity DataIC50: <1.00E+3nMAssay Description:Drugs belonging to different classes have been shown to be associated with QT prolongation and in some cases serious ventricular arrhythmias. The mos...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 3(Homo sapiens (Human))
University Of Nebraska Medical Center
Curated by ChEMBL
University Of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of YFP-tagged human TRPC3 expressed in thapsigargin treated HEK293 cells assessed as reduction in amix-induced calcium level by fluo-4 dye...More data for this Ligand-Target Pair