BDBM14776 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phenyl}-5-methyl-7-propyl-3H,4H-imidazo[1,5-a][1,2,4]triazin-4-one::CHEMBL1520::Vardenafil::citric acid;2-[2-ethoxy-5-(4-ethylpiperazino)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one

SMILES: CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1

InChI Key: InChIKey=SECKRCOLJRRGGV-UHFFFAOYSA-N

Data: 2 KI  24 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 14776   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Perilipin-5 (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-dependent 3',5'-cyclic phosphodiesterase (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.708	n/a	n/a	n/a	n/a	n/a	n/a
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O43924/P16499/P18545/P35913/P51160/Q13956 (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-dependent 3',5'-cyclic phosphodiesterase (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
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Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
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Hepatocyte nuclear factor 4-alpha (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	30
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Perilipin-1 (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489] (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779] (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593] (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450] (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-specific 3',5'-cyclic phosphodiesterase [531-875] (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M] (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
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cGMP-dependent 3',5'-cyclic phosphodiesterase [574-941] (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Human)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Glycerophosphocholine phosphodiesterase GPCPD1 (Rat)	BDBM14776 (CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...) Show SMILES Show InChI	GoogleScholar	UniChem		2.95	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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