BDBM8929 5-(6-Methoxy-2-naphthyl)pyrimidine::5-(6-methoxynaphthalen-2-yl)pyrimidine::Pyrimidine-substituted naphthalene 30::US20230322715, Compound FTO-5

SMILES COc1ccc2cc(ccc2c1)-c1cncnc1

InChI Key InChIKey=NTAKRPRPHWFEKU-UHFFFAOYSA-N

Data  2 IC50  1 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8929   

TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Saarland University

LigandPNGBDBM8929(5-(6-Methoxy-2-naphthyl)pyrimidine | 5-(6-methoxyn...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRNA demethylase ALKBH5(Homo sapiens)
The Regents Of The University Of California

US Patent
LigandPNGBDBM8929(5-(6-Methoxy-2-naphthyl)pyrimidine | 5-(6-methoxyn...)
Affinity DataIC50: >4.00E+4nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM8929(5-(6-Methoxy-2-naphthyl)pyrimidine | 5-(6-methoxyn...)
Affinity DataIC50:  1.34E+4nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent