BDBM9062 5,6-Dimethoxy-2-{[6-(1,2,3,4-tetrahydro-acridin-9-ylamino)-hexylamino]-methyl}-indan-1-one::5,6-dimethoxy-2-({[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]amino}methyl)-2,3-dihydro-1H-inden-1-one::Donepezil-tacrine hybrid 7

SMILES COc1cc2CC(CNCCCCCCNc3c4CCCCc4nc4ccccc34)C(=O)c2cc1OC

InChI Key InChIKey=UPIDGCOPWCTVFP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9062   

TargetCholinesterase(Homo sapiens (Human))
Neuropharma

LigandPNGBDBM9062(5,6-Dimethoxy-2-{[6-(1,2,3,4-tetrahydro-acridin-9-...)
Affinity DataIC50:  50nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Neuropharma

LigandPNGBDBM9062(5,6-Dimethoxy-2-{[6-(1,2,3,4-tetrahydro-acridin-9-...)
Affinity DataIC50:  100nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed