BDBM92336 Dipeptide nitrile, 10

SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC#N)C#N

InChI Key InChIKey=NHZZJQFLKHUHMA-GJZGRUSLSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 92336   

TargetCathepsin B(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi: >330nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi:  840nM ΔG°:  -8.62kcal/molepH: 6.5 T: 2°CAssay Description:Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Bos taurus (bovine))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi:  900nM ΔG°:  -8.57kcal/molepH: 6.0 T: 2°CAssay Description:Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi:  1.10E+3nM ΔG°:  -8.12kcal/molepH: 6.5 T: 2°CAssay Description:Papain enzyme activities were determined by spectrophotometric detection of the product p-nitroaniline at 25 C in a a multicell holder (parallel meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM92336(Dipeptide nitrile, 10)
Affinity DataKi:  6.30E+3nM ΔG°:  -7.38kcal/molepH: 5.0 T: 2°CAssay Description:Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed