BDBM92354 Sorafenib derivative, 17

SMILES OC(=O)CCCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1

InChI Key InChIKey=ARPOPTBHSCEKRP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 92354   

TargetPutative glycogen synthase kinase 3 alpha(Ustilago maydis (Smut fungus))
Technische UniversitÄT Dortmund

LigandPNGBDBM92354(Sorafenib derivative, 17)
Affinity DataIC50:  154nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Central Lancashire

Curated by ChEMBL
LigandPNGBDBM92354(Sorafenib derivative, 17)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human GSK-3beta using Ser/Thr 6 peptide as substrate preincubated for 60 mins followed by ATP and substrate addition and measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Central Lancashire

Curated by ChEMBL
LigandPNGBDBM92354(Sorafenib derivative, 17)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed