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BDBM9480 7-[2-(1H-Imidazol-1-yl)ethoxy]-2H-chromen-2-one::Coumarin deriv. 29

SMILES: O=c1ccc2ccc(OCCn3ccnc3)cc2o1

InChI Key: InChIKey=JUOCDQIZOPYANC-UHFFFAOYSA-N

Data: 1 Other

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9480   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 17A1


(Homo sapiens (human))
BDBM9480
PNG
(7-[2-(1H-Imidazol-1-yl)ethoxy]-2H-chromen-2-one | ...)
Show SMILES O=c1ccc2ccc(OCCn3ccnc3)cc2o1
Show InChI InChI=1S/C14H12N2O3/c17-14-4-2-11-1-3-12(9-13(11)19-14)18-8-7-16-6-5-15-10-16/h1-6,9-10H,7-8H2
PDB

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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/an/an/an/an/an/a



University of Bari



Assay Description
The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...


J Med Chem 47: 6792-803 (2004)

More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM9480
PNG
(7-[2-(1H-Imidazol-1-yl)ethoxy]-2H-chromen-2-one | ...)
Show SMILES O=c1ccc2ccc(OCCn3ccnc3)cc2o1
Show InChI InChI=1S/C14H12N2O3/c17-14-4-2-11-1-3-12(9-13(11)19-14)18-8-7-16-6-5-15-10-16/h1-6,9-10H,7-8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/an/an/an/a7.430



University of Bari



Assay Description
The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta, 2beta-3H] testosterone or [1beta-3H] androstenedione during aroma...


J Med Chem 47: 6792-803 (2004)

More data for this
Ligand-Target Pair