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BDBM98398 US8481733, 210

SMILES: Nc1nccn2c(nc(-c3ccc(Oc4ccccc4F)c(F)c3)c12)C1CCC1

InChI Key: InChIKey=VWVFHJUUFWCMIQ-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 98398   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase non-receptor protein 2


(Homo sapiens (Human))
BDBM98398
PNG
(US8481733, 210)
Show SMILES Nc1nccn2c(nc(-c3ccc(Oc4ccccc4F)c(F)c3)c12)C1CCC1
Show InChI InChI=1S/C22H18F2N4O/c23-15-6-1-2-7-17(15)29-18-9-8-14(12-16(18)24)19-20-21(25)26-10-11-28(20)22(27-19)13-4-3-5-13/h1-2,6-13H,3-5H2,(H2,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.95E+3n/an/an/an/an/an/a



OSI Pharmaceuticals LLC

US Patent


Assay Description
AlphaScreen (amplified luminescent proximity homogeneous assay) assay was used to test for ACK1 inhibitory activity.


US Patent US8481733 (2013)


BindingDB Entry DOI: 10.7270/Q2XD109J
More data for this
Ligand-Target Pair