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BDBM98618 2-amino-1-ethyl-7-[3-hydroxy-3-(3-thienyl)but-1-ynyl]-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide::US8470847, 80::US8470847, 81

SMILES: CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)c1ccsc1

InChI Key: InChIKey=VVHCCEBTRHOKIX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 98618   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM98618
PNG
(2-amino-1-ethyl-7-[3-hydroxy-3-(3-thienyl)but-1-yn...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)c1ccsc1
Show InChI InChI=1S/C20H20N4O3S/c1-4-24-17(21)15(19(26)22-3)16(25)14-6-5-13(23-18(14)24)7-9-20(2,27)12-8-10-28-11-12/h5-6,8,10-11,27H,4,21H2,1-3H3,(H,22,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 38n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.


US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM98618
PNG
(2-amino-1-ethyl-7-[3-hydroxy-3-(3-thienyl)but-1-yn...)
Show SMILES CCn1c(N)c(C(=O)NC)c(=O)c2ccc(nc12)C#CC(C)(O)c1ccsc1
Show InChI InChI=1S/C20H20N4O3S/c1-4-24-17(21)15(19(26)22-3)16(25)14-6-5-13(23-18(14)24)7-9-20(2,27)12-8-10-28-11-12/h5-6,8,10-11,27H,4,21H2,1-3H3,(H,22,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/an/a20



Sanofi

US Patent


Assay Description
Activity of VEGFR-3 is measured by ELISA assay by measuring the intensity of phosphorylation of the substrate poly Glu-Tyr.


US Patent US8470847 (2013)


BindingDB Entry DOI: 10.7270/Q2WD3Z67
More data for this
Ligand-Target Pair