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BDBM99526 US8501936, 24

SMILES: CNC(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccccc3OC)nc12

InChI Key: InChIKey=ZURNMMAFVYXNHL-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 99526   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM99526
PNG
(US8501936, 24)
Show SMILES CNC(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccccc3OC)nc12
Show InChI InChI=1S/C21H19N5O2/c1-22-20(27)15-11-9-14(10-12-15)16-6-5-13-26-19(16)24-21(25-26)23-17-7-3-4-8-18(17)28-2/h3-13H,1-2H3,(H,22,27)(H,23,25)
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PC cid
PC sid
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Similars

US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



Cephalon Inc

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...


US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM99526
PNG
(US8501936, 24)
Show SMILES CNC(=O)c1ccc(cc1)-c1cccn2nc(Nc3ccccc3OC)nc12
Show InChI InChI=1S/C21H19N5O2/c1-22-20(27)15-11-9-14(10-12-15)16-6-5-13-26-19(16)24-21(25-26)23-17-7-3-4-8-18(17)28-2/h3-13H,1-2H3,(H,22,27)(H,23,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.00E+4n/an/an/an/an/an/a



Cephalon Inc

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...


US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair