BDBM99537 CHEMBL2062804::US8501936, 35

SMILES CN1CCN(CC1)c1cccc(Nc2nc3c(cccn3n2)-c2ccc(cc2)S(C)(=O)=O)c1

InChI Key InChIKey=RFZKSQIFOZZIAQ-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 99537   

TargetFocal adhesion kinase 1(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM99537(CHEMBL2062804 | US8501936, 35)
Affinity DataIC50:  1.06E+3nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM99537(CHEMBL2062804 | US8501936, 35)
Affinity DataIC50:  1.30nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM99537(CHEMBL2062804 | US8501936, 35)
Affinity DataIC50:  84.7nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM99537(CHEMBL2062804 | US8501936, 35)
Affinity DataIC50:  81nMAssay Description:Inhibition of human JAK1 expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-University Of Bonn

Curated by ChEMBL
LigandPNGBDBM99537(CHEMBL2062804 | US8501936, 35)
Affinity DataEC50:  202nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM99537(CHEMBL2062804 | US8501936, 35)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human JAK2 expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM99537(CHEMBL2062804 | US8501936, 35)
Affinity DataIC50:  150nMAssay Description:Inhibition of human JAK3 expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM99537(CHEMBL2062804 | US8501936, 35)
Affinity DataIC50:  61nMAssay Description:Inhibition of JAK2 in human TF-1 cells using GM-CSF pretreated for 1 hr prior to GM-CSF addition measured after 5 hrs by FRET based GeneBLAzer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM99537(CHEMBL2062804 | US8501936, 35)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed