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BDBM99881 US8501936, 400

SMILES: COc1ccccc1CNc1cccn2nc(Nc3cccnc3)nc12

InChI Key: InChIKey=YRSJCJDBBQFLOM-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 99881   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM99881
PNG
(US8501936, 400)
Show SMILES COc1ccccc1CNc1cccn2nc(Nc3cccnc3)nc12
Show InChI InChI=1S/C19H18N6O/c1-26-17-9-3-2-6-14(17)12-21-16-8-5-11-25-18(16)23-19(24-25)22-15-7-4-10-20-13-15/h2-11,13,21H,12H2,1H3,(H,22,24)
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PC cid
PC sid
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Similars

US Patent
n/an/a 32.3n/an/an/an/an/an/a



Cephalon Inc

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...


US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM99881
PNG
(US8501936, 400)
Show SMILES COc1ccccc1CNc1cccn2nc(Nc3cccnc3)nc12
Show InChI InChI=1S/C19H18N6O/c1-26-17-9-3-2-6-14(17)12-21-16-8-5-11-25-18(16)23-19(24-25)22-15-7-4-10-20-13-15/h2-11,13,21H,12H2,1H3,(H,22,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.12E+3n/an/an/an/an/an/a



Cephalon Inc

US Patent


Assay Description
The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...


US Patent US8501936 (2013)


BindingDB Entry DOI: 10.7270/Q22Z1455
More data for this
Ligand-Target Pair