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Found 119 Enz. Inhib. hit(s) with Target = 'Pro-cathepsin H'
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167290((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-isopropy...)
Affinity DataKi:  0.460nMAssay Description:Inhibition constant against human cathepsin H using L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167289((1S)-2-cyclohexyl-1-methylethyl 2-cyano-2-methylhy...)
Affinity DataKi:  1.40nMAssay Description:Inhibition constant against human cathepsin H using L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50247192((S)-2-amino-N-((S)-5-phenyl-1-(phenylsulfonyl)pent...)
Affinity DataKi:  137nMAssay Description:Inhibition of human recombinant cathepsin H by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50464764(CHEMBL4287663)
Affinity DataKi:  1.30E+3nMAssay Description:Reversible competitive inhibition of human cathepsin H using fluorogenic AMC-derived peptide substrate assessed as reduction in residual activity pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50243232(CHEMBL486232 | GNF-PF-5434 | N-((S)-4-methyl-1-oxo...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human recombinant cathepsin H by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50186088((S)-2-amino-N-((S)-2-(biphenyl-4-yl)-1-cyanoethyl)...)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of human recombinant cathepsin H by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50464766(CHEMBL4292287)
Affinity DataKi:  7.00E+3nMAssay Description:Reversible competitive inhibition of human cathepsin H using fluorogenic AMC-derived peptide substrate assessed as reduction in residual activity pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286441((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of human liver cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286441((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of human liver cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50167297((Cyano-methyl-amino)-acetic acid (S)-2-cyclohexyl-...)
Affinity DataKi: >1.30E+4nMAssay Description:Inhibition constant against human cathepsin H using L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50460480(CHEMBL4229176)
Affinity DataKi:  8.90E+4nMAssay Description:Non-competitive inhibition of human liver cathepsin H assessed as inhibitory constant for enzyme-substrate-inhibitor complex using R-AMC as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50460480(CHEMBL4229176)
Affinity DataKi:  8.90E+4nMAssay Description:Non-competitive inhibition of human liver cathepsin H assessed as inhibitory constant for enzyme-inhibitor complex using R-AMC as substrate in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50074051(3-(1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-1-...)
Affinity DataKi:  9.30E+4nMAssay Description:Inhibition constant for the non time dependent inhibition of cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50460493(CHEMBL4228921)
Affinity DataKi:  1.08E+5nMAssay Description:Competitive inhibition of human liver cathepsin H assessed as inhibitory constant for enzyme-inhibitor complex using R-AMC as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50425030(CHEMBL2312216)
Affinity DataKi:  1.29E+5nMAssay Description:Noncompetitive inhibition of human liver cathepsin H endopeptidase activity using R-AMC substrate assessed as inhibition constant for enzyme-inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50425030(CHEMBL2312216)
Affinity DataKi:  1.29E+5nMAssay Description:Noncompetitive inhibition of human liver cathepsin H endopeptidase activity using R-AMC substrate assessed as inhibition constant for enzyme-substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50074050(3-(1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-1-...)
Affinity DataKi:  1.37E+5nMAssay Description:Inhibition constant for the non time dependent inhibition of cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50074052(1-(2-Benzyloxycarbonylamino-propionyl)-aziridine-2...)
Affinity DataKi:  1.60E+5nMAssay Description:Inhibition constant for the non time dependent inhibition of Cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50074048(1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propion...)
Affinity DataKi:  2.10E+5nMAssay Description:Compound was evaluated for inhibition constant for the non-time dependent inhibition of Cathepsin H.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50425024(CHEMBL2312204)
Affinity DataKi:  2.21E+5nMAssay Description:Noncompetitive inhibition of human liver cathepsin H endopeptidase activity using R-AMC substrate assessed as inhibition constant for enzyme-substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50425024(CHEMBL2312204)
Affinity DataKi:  2.21E+5nMAssay Description:Noncompetitive inhibition of human liver cathepsin H endopeptidase activity using R-AMC substrate assessed as inhibition constant for enzyme-inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415097(CHEMBL570897)
Affinity DataKi:  2.51E+5nMAssay Description:Uncompetitive inhibition of human liver cathepsin H endopeptidase activity using R-AMC substrate assessed as inhibition constant for enzyme-substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50074049(3-((S)-1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl...)
Affinity DataKi:  2.60E+5nMAssay Description:Inhibition constant for the non time dependent inhibition of cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50460502(CHEMBL4228576)
Affinity DataKi:  3.29E+5nMAssay Description:Non-competitive inhibition of human liver cathepsin H assessed as inhibitory constant for enzyme-inhibitor complex using R-AMC as substrate in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50460502(CHEMBL4228576)
Affinity DataKi:  3.29E+5nMAssay Description:Non-competitive inhibition of human liver cathepsin H assessed as inhibitory constant for enzyme-substrate-inhibitor complex using R-AMC as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50425017(CHEMBL2312203)
Affinity DataKi:  3.54E+5nMAssay Description:Uncompetitive inhibition of human liver cathepsin H endopeptidase activity using R-AMC substrate assessed as inhibition constant for enzyme-substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50460481(CHEMBL4228126)
Affinity DataKi:  4.62E+5nMAssay Description:Uncompetitive inhibition of human liver cathepsin H assessed as inhibitory constant for enzyme-substrate-inhibitor complex using R-AMC as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50255753(CHEMBL481611 | MK-0822 | Odanacatib)
Affinity DataIC50: >10nMAssay Description:Inhibition of cathepsin HMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148298(((S)-1-Formyl-pentyl)-carbamic acid (R)-1-benzyl-2...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50148296(((S)-1-Formyl-pentyl)-carbamic acid (S)-1-methyl-2...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50163831((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50:  110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50:  110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50:  110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM397464(US10676470, Compound 43 | US10730826, Compound 73 ...)
Affinity DataIC50:  110nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50250152(3-acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroq...)
Affinity DataIC50:  145nMAssay Description:Inhibition of human liver cathepsin H after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  190nMAssay Description:Inhibition of human recombinant cathepsin H after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50177501(CHEMBL203663 | {(S)-1-[(morpholine-4-carbonyl)-hyd...)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50177494(CHEMBL204605 | {(S)-1-[(morpholine-4-carbonyl)-hyd...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant human cathepsin H in a fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50152524((S)-(1-(4-fluorobenzyl)cyclobutyl)methyl 1-(1H-pyr...)
Affinity DataIC50: >500nMAssay Description:Inhibition of 50 uM L-Arg-beta-naphthalamide binding to human cathepsin H in fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50165424((S)-4,4-dimethyl-2-oxo-tetrahydrofuran-3-yl (S)-1,...)
Affinity DataIC50: >500nMAssay Description:Inhibitory concentration against human cathepsin H by fluorescence assay using 50 uM L-Arg-b-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)
Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)
Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM553804(US11325884, Compound 1a-non-racemic | US11325884, ...)
Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453275(BDBM453327 | US10730826, Compound 1a-non-racemic |...)
Affinity DataIC50:  560nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50163832((1S)-2-cyclohexyl-1-methylethyl (2S)-1-cyanopyrrol...)
Affinity DataIC50:  580nMAssay Description:Inhibitory concentration against human cathepsin H using 50 uM L-Arg-beta-naphthalamideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50:  1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50:  1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50:  1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPro-cathepsin H(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM453289(US10730826, Compound 2a | US11325884, Compound 2a)
Affinity DataIC50:  1.55E+3nMAssay Description:The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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