Affinity DataKi: 60nMAssay Description:Binding affinity to IL2 assessed as inhibition of IL2-IL2Ralpha interactionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Binding affinity to recombinant human flag/His-tagged IL-23R (1 to 353 residues) expressed in HEK293F cells assessed as disruption of biotinylated IL...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:The compound was evaluated in vitro for the immunosuppressive activity in interleukin-2 by interleukin-2 reporter gene assay (IL2-RGA)More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Binding affinity to recombinant human flag/His-tagged IL-23R (1 to 353 residues) expressed in HEK293F cells assessed as disruption of biotinylated IL...More data for this Ligand-Target Pair
Affinity DataIC50: 6.40nMAssay Description:Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 8nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 9nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 9nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 9nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 10nMAssay Description:Inhibition of IL-2 in CD3/CD28 activated human CD4+ve Th cells preincubated for 15 mins followed by addition of immuno-cult and measured after 24 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 10nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 10nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 10nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 10nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 11nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 11nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 11nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 11nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 11nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 11nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 12nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 12nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 12nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 13nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 13nMAssay Description:Inhibition of IL-2 in CD3/CD28 activated human CD4+ve Th cells preincubated for 15 mins followed by addition of immuno-cult and measured after 24 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 13nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 13nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 13nMAssay Description:The compound was evaluated in vitro for the immunosuppressive activity in interleukin-2 by interleukin-2 reporter gene assay (IL2-RGA)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 14nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 14nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 14nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 14nMAssay Description:Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 16.5nMAssay Description:Jurkat cells were placed in a 96 well plate (0.5 million cells per well in 1% FBS medium) then a test compound of this invention was added at differe...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 18nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 18nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 18nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 18nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 18nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 19nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 20nMAssay Description:Human peripheral blood mononuclear cells (PBMCs) are prepared from heparinized human blood by separation over a Ficoll density gradient.PBMCs are sti...More data for this Ligand-Target Pair
Ligand Info