KEGG T01001: 25

Homo sapiens (human): 25

Entry

25                CDS       T01001

Symbol

ABL1, ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl

Name

(RefSeq) ABL proto-oncogene 1, non-receptor tyrosine kinase

K06619

abelson tyrosine-protein kinase 1 [EC:2.7.10.2]

Organism

hsa Homo sapiens (human)

Pathway

hsa04012

ErbB signaling pathway

hsa04014

Ras signaling pathway

hsa04110

Cell cycle

hsa04360

Axon guidance

hsa04722

Neurotrophin signaling pathway

hsa05130

Pathogenic Escherichia coli infection

hsa05200

Pathways in cancer

hsa05206

MicroRNAs in cancer

hsa05208

Chemical carcinogenesis - reactive oxygen species

hsa05220

Chronic myeloid leukemia

hsa05416

Viral myocarditis

Network

nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06219  JAK-STAT signaling (cancer)
nt06223  TNF signaling (cancer)
nt06276  Chronic myeloid leukemia

Element

N00002

BCR-ABL fusion kinase to RAS-ERK signaling pathway

N00048

BCR-ABL fusion kinase to PI3K signaling pathway

N00055

BCR-ABL fusion kinase to Jak-STAT signaling pathway

N01093

Escherichia EspJ/Tir to Actin signaling pathway

N01411

Metals to NFKB signaling pathway

Disease

H00001

B-cell acute lymphoblastic leukemia

H00004

Chronic myeloid leukemia

Drug target

Asciminib (DG03004):

D11403 D11404<JP/US>

Bafetinib:

D10202

Bosutinib (DG00718):

D03252 D09728<JP/US>

Dasatinib (DG00714):

D03658<JP> D06414<JP/US> D12609

Imatinib (DG00710):

D01441<JP/US> D08066

Nilotinib (DG00716):

D06413<JP/US> D08953 D12444 D12854

Olverembatinib:

D12175

Ponatinib (DG00722):

D09950 D09951<JP/US>

Rebastinib (DG01368):

D10334 D10399

Risvodetinib (DG03300):

D12828 D12829

Saracatinib (DG01418):

D09664 D09665

Tozasertib (DG01365):

D08279 D08344

Vodobatinib:

D11786

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    25 (ABL1)
   04014 Ras signaling pathway
    25 (ABL1)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    25 (ABL1)
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    25 (ABL1)
  09158 Development and regeneration
   04360 Axon guidance
    25 (ABL1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    25 (ABL1)
   05206 MicroRNAs in cancer
    25 (ABL1)
   05208 Chemical carcinogenesis - reactive oxygen species
    25 (ABL1)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    25 (ABL1)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    25 (ABL1)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    25 (ABL1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    25 (ABL1)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     25 (ABL1)
Protein kinases [BR:hsa01001]
Non-receptor tyrosine kinases
  ABL family
   25 (ABL1)

SSDB

Motif

Pfam:

PK_Tyr_Ser-Thr Pkinase F_actin_bind SH2 SH3_1 SH3_2 SH3_9 Haspin_kinase Kinase-like SH3_6 ABC1

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

NP_005148

OMIM:

189980

HGNC:

Ensembl:

ENSG00000097007

UniProt:

P00519 Q59FK4

Structure

Position

9:130713043..130887675

AA seq 1130 aa
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE
NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN
SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT
DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI
HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS
DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP
SDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE
HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF
SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP
KPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS
CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTV
TPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS
ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP
PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVL
PATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPE
RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNK
FAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR

NT seq 3393 nt +upstreamnt +downstreamnt
atgttggagatctgcctgaagctggtgggctgcaaatccaagaaggggctgtcctcgtcc
tccagctgttatctggaagaagcccttcagcggccagtagcatctgactttgagcctcag
ggtctgagtgaagccgctcgttggaactccaaggaaaaccttctcgctggacccagtgaa
aatgaccccaaccttttcgttgcactgtatgattttgtggccagtggagataacactcta
agcataactaaaggtgaaaagctccgggtcttaggctataatcacaatggggaatggtgt
gaagcccaaaccaaaaatggccaaggctgggtcccaagcaactacatcacgccagtcaac
agtctggagaaacactcctggtaccatgggcctgtgtcccgcaatgccgctgagtatctg
ctgagcagcgggatcaatggcagcttcttggtgcgtgagagtgagagcagtcctggccag
aggtccatctcgctgagatacgaagggagggtgtaccattacaggatcaacactgcttct
gatggcaagctctacgtctcctccgagagccgcttcaacaccctggccgagttggttcat
catcattcaacggtggccgacgggctcatcaccacgctccattatccagccccaaagcgc
aacaagcccactgtctatggtgtgtcccccaactacgacaagtgggagatggaacgcacg
gacatcaccatgaagcacaagctgggcgggggccagtacggggaggtgtacgagggcgtg
tggaagaaatacagcctgacggtggccgtgaagaccttgaaggaggacaccatggaggtg
gaagagttcttgaaagaagctgcagtcatgaaagagatcaaacaccctaacctggtgcag
ctccttggggtctgcacccgggagcccccgttctatatcatcactgagttcatgacctac
gggaacctcctggactacctgagggagtgcaaccggcaggaggtgaacgccgtggtgctg
ctgtacatggccactcagatctcgtcagccatggagtacctggagaagaaaaacttcatc
cacagagatcttgctgcccgaaactgcctggtaggggagaaccacttggtgaaggtagct
gattttggcctgagcaggttgatgacaggggacacctacacagcccatgctggagccaag
ttccccatcaaatggactgcacccgagagcctggcctacaacaagttctccatcaagtcc
gacgtctgggcatttggagtattgctttgggaaattgctacctatggcatgtccccttac
ccgggaattgacctgtcccaggtgtatgagctgctagagaaggactaccgcatggagcgc
ccagaaggctgcccagagaaggtctatgaactcatgcgagcatgttggcagtggaatccc
tctgaccggccctcctttgctgaaatccaccaagcctttgaaacaatgttccaggaatcc
agtatctcagacgaagtggaaaaggagctggggaaacaaggcgtccgtggggctgtgagt
accttgctgcaggccccagagctgcccaccaagacgaggacctccaggagagctgcagag
cacagagacaccactgacgtgcctgagatgcctcactccaagggccagggagagagcgat
cctctggaccatgagcctgccgtgtctccattgctccctcgaaaagagcgaggtcccccg
gagggcggcctgaatgaagatgagcgccttctccccaaagacaaaaagaccaacttgttc
agcgccttgatcaagaagaagaagaagacagccccaacccctcccaaacgcagcagctcc
ttccgggagatggacggccagccggagcgcagaggggccggcgaggaagagggccgagac
atcagcaacggggcactggctttcacccccttggacacagctgacccagccaagtcccca
aagcccagcaatggggctggggtccccaatggagccctccgggagtccgggggctcaggc
ttccggtctccccacctgtggaagaagtccagcacgctgaccagcagccgcctagccacc
ggcgaggaggagggcggtggcagctccagcaagcgcttcctgcgctcttgctccgcctcc
tgcgttccccatggggccaaggacacggagtggaggtcagtcacgctgcctcgggacttg
cagtccacgggaagacagtttgactcgtccacatttggagggcacaaaagtgagaagccg
gctctgcctcggaagagggcaggggagaacaggtctgaccaggtgacccgaggcacagta
acgcctccccccaggctggtgaaaaagaatgaggaagctgctgatgaggtcttcaaagac
atcatggagtccagcccgggctccagcccgcccaacctgactccaaaacccctccggcgg
caggtcaccgtggcccctgcctcgggcctcccccacaaggaagaagctggaaagggcagt
gccttagggacccctgctgcagctgagccagtgacccccaccagcaaagcaggctcaggt
gcaccagggggcaccagcaagggccccgccgaggagtccagagtgaggaggcacaagcac
tcctctgagtcgccagggagggacaaggggaaattgtccaggctcaaacctgccccgccg
cccccaccagcagcctctgcagggaaggctggaggaaagccctcgcagagcccgagccag
gaggcggccggggaggcagtcctgggcgcaaagacaaaagccacgagtctggttgatgct
gtgaacagtgacgctgccaagcccagccagccgggagagggcctcaaaaagcccgtgctc
ccggccactccaaagccacagtccgccaagccgtcggggacccccatcagcccagccccc
gttccctccacgttgccatcagcatcctcggccctggcaggggaccagccgtcttccacc
gccttcatccctctcatatcaacccgagtgtctcttcggaaaacccgccagcctccagag
cggatcgccagcggcgccatcaccaagggcgtggtcctggacagcaccgaggcgctgtgc
ctcgccatctctaggaactccgagcagatggccagccacagcgcagtgctggaggccggc
aaaaacctctacacgttctgcgtgagctatgtggattccatccagcaaatgaggaacaag
tttgccttccgagaggccatcaacaaactggagaataatctccgggagcttcagatctgc
ccggcgacagcaggcagtggtccagcggccactcaggacttcagcaagctcctcagttcg
gtgaaggaaatcagtgacatagtgcagaggtag

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