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4GB9:
Potent and Highly Selective Benzimidazole Inhibitors of PI3K-delta
PDB ID:
4GB9
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MMDB ID:
102272
PDB Deposition Date:
2012/7/26
Updated in MMDB:
2023/09
Experimental Method:
x-ray diffraction
Resolution:
2.438 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4GB9: monomeric; determined by author and by software (PISA)
Molecular Components in 4GB9
Label
Count
Molecule
Protein (1 molecule)
A
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Gamma Isoform
(Gene symbol:
PIK3CG
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-[1-({2-[2-(dimethylamino)-1H-benzimidazol-1-yl]-9-methyl-6-(morpholin-4-yl)-9H-purin-8-yl}methyl)piperidin-4-yl]propan-2-ol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303