4LWW: Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

PDB ID: 4LWWDownload
MMDB ID: 116275
PDB Deposition Date: 2013/7/28
Updated in MMDB: 2013/12
Experimental Method:
x-ray diffraction
Resolution: 1.641  Å
Source Organism:
Similar Structures:
Biological Unit for 4LWW: dimeric; determined by author and by software (PISA)
Molecular Components in 4LWW
Label Count Molecule
Proteins (2 molecules)
2
Nicotinamide Phosphoribosyltransferase
(Gene symbol: NAMPT)
Molecule annotation
Chemicals and Non-standard biopolymers (25 molecules)
1
2
N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamideN-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
2
4
PHOSPHATE IONPHOSPHATE ION
3
19
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303