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4L7S:
Kinase domain mutant of human Itk in complex with an aminobenzothiazole inhibitor
PDB ID:
4L7S
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MMDB ID:
116833
PDB Deposition Date:
2013/6/14
Updated in MMDB:
2014/10
Experimental Method:
x-ray diffraction
Resolution:
2.03 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4L7S: monomeric; determined by author
Molecular Components in 4L7S
Label
Count
Molecule
Protein (1 molecule)
A
1
Tyrosine-protein Kinase Itk/tsk
(Gene symbol:
ITK
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303