4L7S: Kinase domain mutant of human Itk in complex with an aminobenzothiazole inhibitor

PDB ID: 4L7SDownload
MMDB ID: 116833
PDB Deposition Date: 2013/6/14
Updated in MMDB: 2014/10
Experimental Method:
x-ray diffraction
Resolution: 2.03  Å
Source Organism:
Similar Structures:
Biological Unit for 4L7S: monomeric; determined by author
Molecular Components in 4L7S
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Itk/tsk
(Gene symbol: ITK)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanoltrans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303