Abstract
The synthesis, acetylcholinesterase inhibitory capacity and structure-activity relationships of simple-structured m-Aminobenzoic acid derivatives are reported. Compound 1b was found to be more potent than galanthamine and tacrine in inhibiting acetylcholinesterase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Aminobenzoic Acid / chemical synthesis*
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4-Aminobenzoic Acid / pharmacology
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Animals
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Cholinesterase Inhibitors / chemical synthesis*
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Cholinesterase Inhibitors / pharmacology
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Humans
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Hydrophobic and Hydrophilic Interactions
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Inhibitory Concentration 50
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Models, Molecular
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Molecular Conformation
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Structure-Activity Relationship
Substances
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Cholinesterase Inhibitors
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4-Aminobenzoic Acid