Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease

Bioorg Med Chem. 2014 Apr 15;22(8):2496-507. doi: 10.1016/j.bmc.2014.02.046. Epub 2014 Mar 7.

Abstract

Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining quinolinecarboxamide to a benzylpiperidine moiety are described. Then, a series of hybrids have been developed by introducing radical scavengers. Molecular modeling was performed and structure activity relationships are discussed. Among the series, most potent compounds show effective AchE inhibitions, high selectivities over butyrylcholinesterase and high radical scavenging activities. On the basis of this work, the ability of quinolone derivatives to serve in the design of N-benzylpiperidine linked multipotent molecules for the treatment of Alzheimer Disease has been established.

Keywords: Acetylcholinesterase; Antioxidant; Hybrid; N-Benzylpiperidine; Quinolone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / chemistry*
  • Acetylcholinesterase / metabolism
  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / enzymology
  • Alzheimer Disease / pathology
  • Antioxidants / chemistry*
  • Antioxidants / metabolism
  • Binding Sites
  • Catalytic Domain
  • Cholinesterase Inhibitors / chemical synthesis
  • Cholinesterase Inhibitors / chemistry*
  • Cholinesterase Inhibitors / metabolism
  • Cholinesterase Inhibitors / therapeutic use
  • Humans
  • Molecular Docking Simulation
  • Piperidines / chemistry*
  • Piperidines / therapeutic use
  • Quinolones / chemistry*
  • Structure-Activity Relationship

Substances

  • Antioxidants
  • Cholinesterase Inhibitors
  • Piperidines
  • Quinolones
  • 1-benzylpiperidine
  • Acetylcholinesterase