Inhibition of electric eel acetylcholinesterase by porphin compounds

B H Lee; M B Park; B S Yu

doi:10.1016/s0960-894x(98)00236-4

Inhibition of electric eel acetylcholinesterase by porphin compounds

Bioorg Med Chem Lett. 1998 Jun 16;8(12):1467-70. doi: 10.1016/s0960-894x(98)00236-4.

Authors

B H Lee¹, M B Park, B S Yu

Affiliation

¹ Department of Industrial Chemistry, Taejon National University of Technology, Korea.

PMID: 9873371
DOI: 10.1016/s0960-894x(98)00236-4

Abstract

Synthetic porphin compounds have been found to be reversible inhibitors of acetylcholinesterase from electric eel with Ki values of microM range. It seems that the number and position of fluorine on the phenyl ring and metal of an inhibitor play an important role for binding of an inhibitor to the enzyme active site.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylcholinesterase / drug effects*
Acetylcholinesterase / metabolism
Animals
Binding Sites
Cholinesterase Inhibitors / metabolism
Cholinesterase Inhibitors / pharmacology*
Electrophorus
Porphyrins / pharmacology*

Substances

Cholinesterase Inhibitors
Porphyrins
Acetylcholinesterase