Synthesis of small molecule CDC25 phosphatases inhibitors

Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12. doi: 10.1016/j.bmcl.2004.09.041.

Abstract

A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Protease Inhibitors / chemical synthesis*
  • Protease Inhibitors / pharmacology*
  • cdc25 Phosphatases / antagonists & inhibitors*
  • cdc25 Phosphatases / metabolism

Substances

  • Protease Inhibitors
  • cdc25 Phosphatases