Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus

Ick-Dong Yoo; Kyung-Mi Cho; Chong-Kil Lee; Won-Gon Kim

doi:10.1016/j.bmcl.2004.10.067

Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus

Bioorg Med Chem Lett. 2005 Jan 17;15(2):353-6. doi: 10.1016/j.bmcl.2004.10.067.

Authors

Ick-Dong Yoo¹, Kyung-Mi Cho, Chong-Kil Lee, Won-Gon Kim

Affiliation

¹ Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Taejon 305-600, Korea.

PMID: 15603953
DOI: 10.1016/j.bmcl.2004.10.067

Abstract

A new seven-membered lactone type meroterpenoid, isoterreulactone A, was isolated from the solid state fermentation of Aspergillus terreus and its structure was established by various spectral analysis. Isoterreulactone A inhibited acetylcholinesterase with an IC(50) value of 2.5 microM while did not inhibit butyrylcholinesterase even at 500 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylcholinesterase / metabolism*
Aspergillus / chemistry*
Butyrylcholinesterase / metabolism
Cholinesterase Inhibitors / isolation & purification*
Cholinesterase Inhibitors / metabolism
Cholinesterase Inhibitors / pharmacology
Fermentation
Inhibitory Concentration 50
Lactones / isolation & purification*
Lactones / metabolism
Lactones / pharmacology
Terpenes / isolation & purification*
Terpenes / metabolism
Terpenes / pharmacology

Substances

Cholinesterase Inhibitors
Lactones
Terpenes
isoterreulactone A
Acetylcholinesterase
Butyrylcholinesterase